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Issue 7, 2012
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Template-directed synthesis of multi-component organic cages in water

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Abstract

We describe here the discovery of a new class of organic cages assembled from simple tri- and dithiol building blocks using dynamic combinatorial chemistry (DCC). These water-soluble disulfide-linked architectures containing up to eleven components are only generated upon templation by positively charged polyamine guests of appropriate shape and length such as spermine and spermidine. The overall response of the system as expressed in the pattern of peaks in an HPLC trace provides an unusual tool for the identification of the templating analyte.

Graphical abstract: Template-directed synthesis of multi-component organic cages in water

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The article was received on 19 Mar 2012, accepted on 23 Apr 2012 and first published on 24 Apr 2012


Article type: Edge Article
DOI: 10.1039/C2SC20347B
Citation: Chem. Sci., 2012,3, 2326-2329
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    Template-directed synthesis of multi-component organic cages in water

    A. R. Stefankiewicz, M. R. Sambrook and J. K. M. Sanders, Chem. Sci., 2012, 3, 2326
    DOI: 10.1039/C2SC20347B

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