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Issue 1, 2012
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Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells

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Abstract

Nanoscale coordination polymers (NCPs) have been demonstrated as an interesting platform for drug delivery, as they possess many advantages over small-molecule chemotherapeutics such as high payloads, lower systemic toxicity, tunability, and enhanced tumor uptake. Existing formulations for the delivery of methotrexate (MTX), an antifolate cancer drug, have very low drug loadings. Herein, we report the incorporation of MTX as a building block in an NCP formulation with exceptionally high drug loadings (up to 79.1 wt%) and the selective delivery of the NCP to cancer cells. Encapsulation of the NCP in a functionalized lipid bilayer allows for targeted delivery and controlled release to cancer cells. A phosphor can be doped into the NCPs for monitoring particle uptake by optical imaging. The lipid-coated and anisamide-targeted NCPs have superior in vitro efficacy against acute lymphoblastic leukemia cells when compared to the free drug.

Graphical abstract: Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells

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Publication details

The article was received on 22 Jul 2011, accepted on 28 Sep 2011 and first published on 20 Oct 2011


Article type: Edge Article
DOI: 10.1039/C1SC00499A
Citation: Chem. Sci., 2012,3, 198-204
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    Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells

    R. C. Huxford, K. E. deKrafft, W. S. Boyle, D. Liu and W. Lin, Chem. Sci., 2012, 3, 198
    DOI: 10.1039/C1SC00499A

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