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Issue 2, 2012
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Aerobic oxidation of thiols to disulfides by heterogeneous gold catalysts

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Abstract

Thiols are smoothly and efficiently oxidized to disulfides (RSSR) with air in the presence of gold nanoparticles supported on CeO2 in absence of solvent, as well as in aqueous solutions and neutral pH. It is shown that the reaction can occur through the coupling of two sulphur radicals on the metal surface. The sulphur radicals are formed from thiols by one-electron oxidation with the metal. This reaction mechanism strongly resembles that found for sulfhydryl oxidases, a class of enzymes which are involved in the oxidative protein folding through de novo formation of disulfides from thiols.

Graphical abstract: Aerobic oxidation of thiols to disulfides by heterogeneous gold catalysts

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Publication details

The article was received on 14 Jul 2011, accepted on 08 Sep 2011 and first published on 18 Oct 2011


Article type: Edge Article
DOI: 10.1039/C1SC00466B
Citation: Chem. Sci., 2012,3, 398-404
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    Aerobic oxidation of thiols to disulfides by heterogeneous gold catalysts

    A. Corma, T. Ródenas and M. J. Sabater, Chem. Sci., 2012, 3, 398
    DOI: 10.1039/C1SC00466B

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