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Issue 30, 2012
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The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

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Abstract

Dendrimers are polymers with a strong role in nanomedicine. In the current work we have developed a platform for mapping out the biomolecule corona for polyamidoamine (PAMAM) dendrimers. Complement proteins including C3 and C4b were found for the high generation dendrimers, suggesting high affinities to the dendrimers and most importantly complement activation.

Graphical abstract: The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

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Publication details

The article was received on 18 Aug 2012, accepted on 16 Sep 2012 and first published on 21 Sep 2012


Article type: Communication
DOI: 10.1039/C2RA21866F
Citation: RSC Adv., 2012,2, 11245-11248
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    The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

    A. Åkesson, M. Cárdenas, G. Elia, M. P. Monopoli and K. A. Dawson, RSC Adv., 2012, 2, 11245
    DOI: 10.1039/C2RA21866F

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