Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 30, 2012
Previous Article Next Article

The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

Author affiliations

Abstract

Dendrimers are polymers with a strong role in nanomedicine. In the current work we have developed a platform for mapping out the biomolecule corona for polyamidoamine (PAMAM) dendrimers. Complement proteins including C3 and C4b were found for the high generation dendrimers, suggesting high affinities to the dendrimers and most importantly complement activation.

Graphical abstract: The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 18 Aug 2012, accepted on 16 Sep 2012 and first published on 21 Sep 2012


Article type: Communication
DOI: 10.1039/C2RA21866F
Citation: RSC Adv., 2012,2, 11245-11248
  •   Request permissions

    The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

    A. Åkesson, M. Cárdenas, G. Elia, M. P. Monopoli and K. A. Dawson, RSC Adv., 2012, 2, 11245
    DOI: 10.1039/C2RA21866F

Search articles by author