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Issue 32, 2012
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Mesoporous silica-coated NaYF4 nanocrystals: facile synthesis, in vitro bioimaging and photodynamic therapy of cancer cells

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Abstract

Up-conversion nanoparticles (UCNPs) that emit high-energy photons upon excitation by low-energy near-infrared (NIR) radiation are emerging as new optical nanoprobes useful in biomedicine. Herein, the one pot facile synthesis of mesoporous silica-coated NaYF4:Yb/Er nanoparticles has been achieved successfully. The as-prepared product was characterized by X-ray power diffraction (XRD), transmission electron microscopy (TEM) and Brunauer–Emmet–Teller (BET) surface area analyses, respectively. The resulting nanoparticles with a BET area of 800 m2 g−1 and an average pore size of 2.6 nm were spherical, highly monodispersed and stable in an aqueous system. Furthermore, the NaYF4:Yb/Er@mesoporous silica nanoparticles also displayed good biocompatibility and could be used for bio-labeling or bio-imaging. Additionally, the results of preliminary photodynamic therapy (PDT) of cancer cells indicated the NaYF4:Yb/Er@mesoporous silica nanoparticles could be used as important photosensitizer carriers for tumor therapy.

Graphical abstract: Mesoporous silica-coated NaYF4 nanocrystals: facile synthesis, in vitro bioimaging and photodynamic therapy of cancer cells

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Publication details

The article was received on 03 Aug 2012, accepted on 07 Oct 2012 and first published on 11 Oct 2012


Article type: Paper
DOI: 10.1039/C2RA21688D
Citation: RSC Adv., 2012,2, 12263-12268
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    Mesoporous silica-coated NaYF4 nanocrystals: facile synthesis, in vitro bioimaging and photodynamic therapy of cancer cells

    X. Liu, H. Qian, Y. Ji, Z. Li, Y. Shao, Y. Hu, G. Tong, L. Li, W. Guo and H. Guo, RSC Adv., 2012, 2, 12263
    DOI: 10.1039/C2RA21688D

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