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Issue 24, 2012
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Bone bonding ability—how to measure it?

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Bone bonding ability can be examined using in vitro assays. However, conventional approaches use static conditions simulating body fluids without biologically relevant compounds (proteins/growth factors). These features could have a major impact on surface properties, thus we investigated the effect of perfusion and simulated body fluid (SBF) composition of medium on the formation of apatite layer on nickel-titanium alloy (NiTi) with modified surfaces. Apatite layer formation in SBF was investigated under three conditions: static, dynamic (perfusion) and dynamic in serum supplemented SBF (S-SBF). It was found that perfusion and protein supplemented media altered results significantly when compared with standard approaches. Adequate media that contained both organic and inorganic phases provided a more accurate model for bone bonding ability testing. It was also confirmed that both plasma modified and ground to a mirror finish (and cleaned) encourage formation of apatite layers in all test conditions, which suggests the positive interaction of the material in bone tissue environment.

Graphical abstract: Bone bonding ability—how to measure it?

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Publication details

The article was received on 15 May 2012, accepted on 03 Aug 2012 and first published on 06 Aug 2012

Article type: Paper
DOI: 10.1039/C2RA20935G
Citation: RSC Adv., 2012,2, 9214-9223
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    Bone bonding ability—how to measure it?

    W. Chrzanowski, W. J. Yeow, R. Rohanizadeh and F. Dehghani, RSC Adv., 2012, 2, 9214
    DOI: 10.1039/C2RA20935G

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