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Issue 21, 2012
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Biodegradable dendritic polymersomes as modular, high-relaxivity MRI contrast agents

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Abstract

A modular approach combining nanoscale components that each contribute to an enhancement in Gd(III) relaxivity is described here. Small molecule and dendritic alkyne derivatives of a Gd(III) complex were conjugated to the surfaces of biodegradable polymersomes resulting in ionic relaxivities of 10.6 mM−1 s−1 and 26.1 mM−1 s−1 respectively.

Graphical abstract: Biodegradable dendritic polymersomes as modular, high-relaxivity MRI contrast agents

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Publication details

The article was received on 09 May 2012, accepted on 07 Jul 2012 and first published on 06 Aug 2012


Article type: Communication
DOI: 10.1039/C2RA20886E
Citation: RSC Adv., 2012,2, 7971-7973
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    Biodegradable dendritic polymersomes as modular, high-relaxivity MRI contrast agents

    A. Nazemi, F. Martínez, T. J. Scholl and E. R. Gillies, RSC Adv., 2012, 2, 7971
    DOI: 10.1039/C2RA20886E

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