Jump to main content
Jump to site search

Issue 15, 2012
Previous Article Next Article

Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

Author affiliations

Abstract

The amination of benzylic and cinnamic alcohols was achieved via a biocatalytic, one-pot oxidation–transamination cascade in aqueous medium at physiological conditions. Alcohol oxidation by galactose oxidase at the expense of O2 furnished the corresponding aldehydes, which were aminated using ω-transaminases in situ. The applicability of this method was demonstrated by a short synthesis of the antifungal agent naftifine.

Graphical abstract: Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Apr 2012, accepted on 02 May 2012 and first published on 12 Jun 2012


Article type: Paper
DOI: 10.1039/C2RA20800H
Citation: RSC Adv., 2012,2, 6262-6265
  •   Request permissions

    Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

    M. Fuchs, K. Tauber, J. Sattler, H. Lechner, J. Pfeffer, W. Kroutil and K. Faber, RSC Adv., 2012, 2, 6262
    DOI: 10.1039/C2RA20800H

Search articles by author

Spotlight

Advertisements