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Issue 14, 2012
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Highly regioselective C–H bond functionalization: palladium-catalyzed arylation of substituted imidazo[1,2-a]pyridine with aryl chlorides

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Abstract

We have developed an efficient Pd-catalyzed regioselective arylation of substituted imidazo[1,2-a]pyridines with aryl chlorides, which is rarely reported. This methodology has been successfully applied to the synthesis of a variety of substituted imidazo[1,2-a]pyridine core π systems which exhibit a wide range of biological activities in many drugs.

Graphical abstract: Highly regioselective C–H bond functionalization: palladium-catalyzed arylation of substituted imidazo[1,2-a]pyridine with aryl chlorides

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Publication details

The article was received on 28 Feb 2012, accepted on 14 May 2012 and first published on 15 May 2012


Article type: Communication
DOI: 10.1039/C2RA20366A
Citation: RSC Adv., 2012,2, 5972-5975
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    Highly regioselective C–H bond functionalization: palladium-catalyzed arylation of substituted imidazo[1,2-a]pyridine with aryl chlorides

    H. Cao, Y. Lin, H. Zhan, Z. Du, X. Lin, Q. Liang and H. Zhang, RSC Adv., 2012, 2, 5972
    DOI: 10.1039/C2RA20366A

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