Issue 14, 2012
From the journal:

RSC Advances

Highly regioselective C–H bond functionalization: palladium-catalyzed arylation of substituted imidazo[1,2-a]pyridine with aryl chlorides†

Hua Cao,*a   Yuanguang Lin,a   Haiying Zhan,a   Zuodong Du,a   Xiulian Lin,a   Qi-Mei Lianga  and  Hong Zhanga  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, P. R. of China
E-mail: hua.cao@mail.scut.edu.cn
Fax: (+)86(760)88207939

Abstract

We have developed an efficient Pd-catalyzed regioselective arylation of substituted imidazo[1,2-a]pyridines with aryl chlorides, which is rarely reported. This methodology has been successfully applied to the synthesis of a variety of substituted imidazo[1,2-a]pyridine core π systems which exhibit a wide range of biological activities in many drugs.

Graphical abstract: Highly regioselective C–H bond functionalization: palladium-catalyzed arylation of substituted imidazo[1,2-a]pyridine with aryl chlorides

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Article information

DOI
https://doi.org/10.1039/C2RA20366A
Article type
Communication
Submitted
28 Feb 2012
Accepted
14 May 2012
First published
15 May 2012

RSC Adv., 2012,2, 5972-5975

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Highly regioselective C–H bond functionalization: palladium-catalyzed arylation of substituted imidazo[1,2-a]pyridine with aryl chlorides

H. Cao, Y. Lin, H. Zhan, Z. Du, X. Lin, Q. Liang and H. Zhang, RSC Adv., 2012, 2, 5972 DOI: 10.1039/C2RA20366A

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