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Issue 9, 2012
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Engineering of Brome mosaic virus for biomedical applications

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Abstract

Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.

Graphical abstract: Engineering of Brome mosaic virus for biomedical applications

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Publication details

The article was received on 30 Dec 2011, accepted on 18 Jan 2012 and first published on 23 Jan 2012


Article type: Paper
DOI: 10.1039/C2RA01376B
Citation: RSC Adv., 2012,2, 3670-3677
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    Engineering of Brome mosaic virus for biomedical applications

    I. Yildiz, I. Tsvetkova, A. M. Wen, S. Shukla, M. H. Masarapu, B. Dragnea and N. F. Steinmetz, RSC Adv., 2012, 2, 3670
    DOI: 10.1039/C2RA01376B

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