Issue 23, 2012

Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes

Abstract

We report a highly practical one-pot method for synthesizing multi-substituted indolizines from α-halide carbonyl compounds, pyridines and electron deficient alkenes in the presence of copper acetate monohydrate and sodium acetate in DMF. A variety of function groups are tolerable in standard reaction conditions, including aldehyde. 36 examples were presented. The yield of indolizine was from moderate to high. Furthermore, multi-substituted indolizines can be prepared at gram scale by this method.

Graphical abstract: Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes

Supplementary files

Article information

Article type
Paper
Submitted
19 Jun 2012
Accepted
06 Jul 2012
First published
14 Aug 2012

RSC Adv., 2012,2, 8637-8644

Copper acetate monohydrate: a cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes

H. Hu, J. Feng, Y. Zhu, N. Gu and Y. Kan, RSC Adv., 2012, 2, 8637 DOI: 10.1039/C2RA21213G

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