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Issue 19, 2012
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An expedient approach to highly enantioenriched cyclic nitrones mediated by robust and recoverable C3-symmetric cinchonine-squaramide catalysts

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Abstract

The C3-symmetric cinchonine-squaramide catalyzed asymmetric Michael addition of β-ketosulfones to nitroalkenes is presented. Subsequent transformation leads to chiral cyclic nitrones with excellent results (up to 85% yield and >99% ee). The catalyst can be recovered and reused for six cycles without losing activity and selectivity.

Graphical abstract: An expedient approach to highly enantioenriched cyclic nitrones mediated by robust and recoverable C3-symmetric cinchonine-squaramide catalysts

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Publication details

The article was received on 11 Jun 2012, accepted on 12 Jun 2012 and first published on 13 Jun 2012


Article type: Paper
DOI: 10.1039/C2RA21162A
Citation: RSC Adv., 2012,2, 7501-7505
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    An expedient approach to highly enantioenriched cyclic nitrones mediated by robust and recoverable C3-symmetric cinchonine-squaramide catalysts

    X. Han, X. Wu, C. Min, H. Zhou and C. Dong, RSC Adv., 2012, 2, 7501
    DOI: 10.1039/C2RA21162A

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