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Issue 11, 2012
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Direct experimental observation of the aggregation of α-amino acids into 100–200 nm clusters in aqueous solution

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Abstract

Spherical supramolecular aggregates of α-amino acids with a typical diameter of 100–200 nm are formed spontaneously after dissolution in water at a concentration of a few mM, i.e. well below the solubility limit. Their presence was shown by nanoparticle tracking analysis (NTA), atomic force microscopy (AFM), and ESI mass spectrometry (ESI-MS). There is a dynamic equilibrium between the aggregates and dissolved individual molecules which allows them to penetrate through dialysis membranes and filters. The same phenomenon was observed for para-amino salicylic acid and two dipeptides. Thermodynamic considerations suggest an entropy-controlled process.

Graphical abstract: Direct experimental observation of the aggregation of α-amino acids into 100–200 nm clusters in aqueous solution

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Publication details

The article was received on 23 Dec 2011, accepted on 14 Mar 2012 and first published on 15 Mar 2012


Article type: Paper
DOI: 10.1039/C2RA01352E
Citation: RSC Adv., 2012,2, 4690-4696
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    Direct experimental observation of the aggregation of α-amino acids into 100–200 nm clusters in aqueous solution

    D. Hagmeyer, J. Ruesing, T. Fenske, H. Klein, C. Schmuck, W. Schrader, M. E. M. D. Piedade and M. Epple, RSC Adv., 2012, 2, 4690
    DOI: 10.1039/C2RA01352E

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