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Issue 10, 2012
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In situ formation of crosslinked core–corona polymeric nanoparticles from a novel hyperbranched core

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Abstract

A facile approach for the preparation of well-controlled crosslinked core–corona (CCC) nanoparticles is described. Firstly, a core containing multiple initiating sites was generated by deactivation enhanced atom transfer radical homopolymerisation (DE-ATRP) of divinylbenzene (DVB). Then, the multiple halide initiating sites on this hyperbranched polyDVB core were used to initiate linear chains of methyl methacrylate (MMA) via ATRP. During the second step, the pendant vinyl groups within the core were consumed, leading to generation of a crosslinked nanogel core within the final polymer structures isolated, whilst linear arms (corona) were simultaneously growing from the periphery. The structure of the resulting CCC nanoparticles was confirmed using 1H NMR spectroscopy, gel permeation chromatography equipped with MALLS (GPC-MALLS), dynamic light scattering (DLS) and atomic force microscopy (AFM).

Graphical abstract: In situ formation of crosslinked core–corona polymeric nanoparticles from a novel hyperbranched core

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Publication details

The article was received on 20 Apr 2012, accepted on 06 Jul 2012 and first published on 09 Jul 2012


Article type: Paper
DOI: 10.1039/C2PY20247F
Citation: Polym. Chem., 2012,3, 2807-2814
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    In situ formation of crosslinked core–corona polymeric nanoparticles from a novel hyperbranched core

    Y. Zheng, K. J. Thurecht, X. Chen, C. J. Roberts, D. J. Irvine, S. M. Howdle and W. Wang, Polym. Chem., 2012, 3, 2807
    DOI: 10.1039/C2PY20247F

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