Jump to main content
Jump to site search

Issue 6, 2012
Previous Article Next Article

Functional block copolymer nanoparticles: toward the next generation of delivery vehicles

Author affiliations

Abstract

The self-assembly of functional block copolymers (BCPs) into dispersed nanoparticles is a powerful technique for the preparation of novel delivery vehicles with precise control of morphology and architecture. Well-defined BCPs containing an alkyne-functional, biodegradable polylactide (PLA) block were synthesized and conjugated with azide-functional coumarin dyes via copper catalyzed azide alkyne cycloaddition ‘click’ chemistry. Self-assembled nanoparticles with internal nanophase-separated morphologies could then be accessed by carefully controlling the composition of the BCPs and release of the covalently attached model payload was shown to occur under physiological conditions via the degradation of the PLA scaffold. These results demonstrate the potential of self-assembled nanoparticles as modular delivery vehicles with multiple functionalities, nanostructures, and compartmentalized internal morphology.

Graphical abstract: Functional block copolymer nanoparticles: toward the next generation of delivery vehicles

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Mar 2012, accepted on 03 Apr 2012 and first published on 18 Apr 2012


Article type: Paper
DOI: 10.1039/C2PY20131C
Citation: Polym. Chem., 2012,3, 1618-1628
  •   Request permissions

    Functional block copolymer nanoparticles: toward the next generation of delivery vehicles

    M. J. Robb, L. A. Connal, B. F. Lee, N. A. Lynd and C. J. Hawker, Polym. Chem., 2012, 3, 1618
    DOI: 10.1039/C2PY20131C

Search articles by author

Spotlight

Advertisements