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Issue 4, 2012
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Synthesis and antibacterial characterization of gemini surfactant monomers and copolymers

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Abstract

A series of novel quaternary ammonium gemini monomers with broad-spectrum antibacterial activities were synthesized with a facile method. The surface tensions at various concentrations of gemini monomers were measured. The antibacterial and antifungal activities of these gemini monomers were evaluated by quantifying the minimal inhibitory concentration (MIC). The results indicated that the quaternary ammonium gemini monomers showed lower surface tensions and good activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as fungi, compared with a commercially available n-dodecyl-trimethylammonium bromide (DTAB). These monomers could be easily copolymerized with N-(3-aminopropyl) methacrylamide hydrochloride (APMA) using free radical polymerization to develop novel antibacterial polymers.

Graphical abstract: Synthesis and antibacterial characterization of gemini surfactant monomers and copolymers

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Publication details

The article was received on 21 Nov 2011, accepted on 01 Jan 2012 and first published on 30 Jan 2012


Article type: Paper
DOI: 10.1039/C2PY00558A
Citation: Polym. Chem., 2012,3, 907-913
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    Synthesis and antibacterial characterization of gemini surfactant monomers and copolymers

    Y. Zhang, M. Ding, L. Zhou, H. Tan, J. Li, H. Xiao, J. Li and J. Snow, Polym. Chem., 2012, 3, 907
    DOI: 10.1039/C2PY00558A

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