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Issue 2, 2012
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A fluorescently labeled, hyperbranched polymer synthesized from DE-ATRP for the detection of DNA hybridization

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Abstract

The early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently been found to be significantly affected in cancer patients, they offer a means of early stage detection of cancer. Towards the goal of creating a novel method of DNA hybridization detection, we report the detection of specific sequences of small oligonucleotides in a model experiment carried out in serum. The results shown here display the versatility of the DE-ATRP method in synthesizing a specific polymer structure capable of changing its physical properties in the presence of double stranded DNA. The polymer was labeled and used to detect single-stranded DNA in serum successfully.

Graphical abstract: A fluorescently labeled, hyperbranched polymer synthesized from DE-ATRP for the detection of DNA hybridization

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Publication details

The article was received on 02 Nov 2011, accepted on 05 Dec 2011 and first published on 19 Dec 2011


Article type: Communication
DOI: 10.1039/C2PY00516F
Citation: Polym. Chem., 2012,3, 332-334
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    A fluorescently labeled, hyperbranched polymer synthesized from DE-ATRP for the detection of DNA hybridization

    A. Aied, B. Glynn, H. Cao, Y. Zheng, H. Tai, A. Pandit and W. Wang, Polym. Chem., 2012, 3, 332
    DOI: 10.1039/C2PY00516F

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