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Issue 6, 2012
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On the mechanism of Candida spp. photoinactivation by hypericin

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Abstract

The photoprocesses involved in hypericin photoinactivation of three different Candida species (C. albicans, C. parapsilosis and C. krusei) have been examined. Production of singlet oxygen from the triplet state and of superoxide from both the triplet state and the semiquinone radical anion are demonstrated. Hydrogen peroxide is formed downstream of these early events. The outcome of the photodynamic treatments is dictated by the intracellular distribution of hypericin, which is different in the three species and affects the ability of hypericin to produce the different reactive oxygen species and trigger cell-death pathways. The results are in line with the previously-observed different susceptibilities of the three Candida species to hypericin photodynamic treatments.

Graphical abstract: On the mechanism of Candida spp. photoinactivation by hypericin

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Publication details

The article was received on 13 Apr 2012, accepted on 18 Apr 2012 and first published on 20 Apr 2012


Article type: Paper
DOI: 10.1039/C2PP25105A
Citation: Photochem. Photobiol. Sci., 2012,11, 1099-1107
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    On the mechanism of Candida spp. photoinactivation by hypericin

    P. López-Chicón, M. P. Paz-Cristobal, A. Rezusta, C. Aspiroz, M. Royo-Cañas, E. Andres-Ciriano, Y. Gilaberte, M. Agut and S. Nonell, Photochem. Photobiol. Sci., 2012, 11, 1099
    DOI: 10.1039/C2PP25105A

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