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Issue 46, 2012
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Highly regioselective nitrile oxide dipolar cycloadditions with ortho-nitrophenyl alkynes

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Abstract

The dipolar cycloadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.

Graphical abstract: Highly regioselective nitrile oxide dipolar cycloadditions with ortho-nitrophenyl alkynes

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Publication details

The article was received on 04 Jul 2012, accepted on 04 Oct 2012 and first published on 23 Oct 2012


Article type: Paper
DOI: 10.1039/C2OB26267C
Citation: Org. Biomol. Chem., 2012,10, 9204-9213
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    Highly regioselective nitrile oxide dipolar cycloadditions with ortho-nitrophenyl alkynes

    M. L. McIntosh, M. R. Naffziger, B. O. Ashburn, L. N. Zakharov and R. G. Carter, Org. Biomol. Chem., 2012, 10, 9204
    DOI: 10.1039/C2OB26267C

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