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Paper

Development of a novel class of B-RafV600E-selective inhibitors through virtual screening and hierarchical hit optimization

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a
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: cluo@mail.shcnc.ac.cn, hliu@mail.shcnc.ac.cn;
Fax: +86-21-50807088 ;
Tel: +86-21-50271399
b
The Wistar Institute, Philadelphia, USA
E-mail: marmor@wistar.org;
Fax: +0-215-898-0381 ;
Tel: +0-215-898-5006
c
Center for Systems Biology, Soochow University, Jiangsu 215006, China
Org. Biomol. Chem., 2012,10, 7402-7417

DOI: 10.1039/C2OB26081F
Received 05 Jun 2012, Accepted 10 Jul 2012
First published online 13 Jul 2012
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