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Development of a novel class of B-RafV600E-selective inhibitors through virtual screening and hierarchical hit optimization

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State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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The Wistar Institute, Philadelphia, USA
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Center for Systems Biology, Soochow University, Jiangsu 215006, China
Org. Biomol. Chem., 2012,10, 7402-7417

DOI: 10.1039/C2OB26081F
Received 05 Jun 2012, Accepted 10 Jul 2012
First published online 13 Jul 2012
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