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Issue 28, 2012
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Synthesis and structure confirmation of fuscachelins A and B, structurally unique natural product siderophores from Thermobifida fusca

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Abstract

The fuscachelin siderophores have been prepared synthetically as have their metal chelation complexes. The heterodimeric nature of the fuscachelin decamer lends itself to a convergent synthetic strategy. Synthetic access to the natural products and intermediates will provide readily adaptable tools in future studies examining iron-sequestration and the biosynthetic machinery.

Graphical abstract: Synthesis and structure confirmation of fuscachelins A and B, structurally unique natural product siderophores from Thermobifida fusca

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Publication details

The article was received on 29 Mar 2012, accepted on 24 May 2012 and first published on 12 Jun 2012


Article type: Communication
DOI: 10.1039/C2OB26010G
Citation: Org. Biomol. Chem., 2012,10, 5353-5356
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    Synthesis and structure confirmation of fuscachelins A and B, structurally unique natural product siderophores from Thermobifida fusca

    E. J. Dimise, H. L. Condurso, G. E. Stoker and S. D. Bruner, Org. Biomol. Chem., 2012, 10, 5353
    DOI: 10.1039/C2OB26010G

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