An efficient stereoselective approach to the tetracyclic core of Cryptotrione, involving an asymmetric Michael addition, ring-closing metathesis, and subsequent cyclopropanation, is described.
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Stereoselective construction of the tetracyclic core of Cryptotrione
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a
Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b
Department of Chemistry, Colorado State University, Fort Collins, USA
E-mail: yian@lamar.colostate.edu ;
Fax: +(1)-970-4911801 ;
Tel: +(1)-970-4917424
E-mail: yian@lamar.colostate.edu ;
Fax: +(1)-970-4911801 ;
Tel: +(1)-970-4917424
Org. Biomol. Chem., 2012,10, 5518-5520
DOI: 10.1039/C2OB25923K
Received 14 May 2012, Accepted 14 Jun 2012
First published online 14 Jun 2012
Organic & Biomolecular Chemistry
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