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Issue 28, 2012
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Palladium-catalyzed cross-coupling of various phosphorus pronucleophiles with chloropyrazines: synthesis of novel Am(III)-selective extractants

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Abstract

Palladium-catalyzed cross-coupling of (di)chloropyrazines with phosphorus pronucleophiles in the presence of a base gave the phosphorylated pyrazines in 81–95% yields. Based on this methodology a series of appropriately functionalized pyrazines was prepared as potential extractants of trivalent cations from highly acidic nuclear waste. A few hydrophilic derivatives exhibited a very good selectivity for Am3+ over Eu3+ with separation factors up to 40 at pH 1 at 0.01 mol L−1 ligand concentration.

Graphical abstract: Palladium-catalyzed cross-coupling of various phosphorus pronucleophiles with chloropyrazines: synthesis of novel Am(iii)-selective extractants

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Publication details

The article was received on 24 Apr 2012, accepted on 01 Jun 2012 and first published on 01 Jun 2012


Article type: Paper
DOI: 10.1039/C2OB25787D
Citation: Org. Biomol. Chem., 2012,10, 5443-5451
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    Palladium-catalyzed cross-coupling of various phosphorus pronucleophiles with chloropyrazines: synthesis of novel Am(III)-selective extractants

    N. I. Nikishkin, J. Huskens, J. Assenmacher, A. Wilden, G. Modolo and W. Verboom, Org. Biomol. Chem., 2012, 10, 5443
    DOI: 10.1039/C2OB25787D

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