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Issue 29, 2012
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Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate

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Abstract

“Click” reactions have become very common and powerful ligation techniques, of which 1,3-dipolar cycloadditions have most frequently been employed. Since metal-mediated cycloadditions are incompatible in biomedical applications due to toxicity issues associated with transition metals like copper, metal-free variants provide important alternatives. The metal-free conjugation process is studied in detail with special emphasis put on the reaction progress. This report unfolds the first aqueous metal-free “click” conjugation of a cyclic RGD-pentapeptide with the biomacromolecule alginate, creating a “smart” bioactive polymer with potential applications in biomedicine.

Graphical abstract: Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate

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Publication details

The article was received on 22 Mar 2012, accepted on 01 Jun 2012 and first published on 13 Jun 2012


Article type: Paper
DOI: 10.1039/C2OB25604E
Citation: Org. Biomol. Chem., 2012,10, 5547-5553
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    Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate

    A. Krause, A. Kirschning and G. Dräger, Org. Biomol. Chem., 2012, 10, 5547
    DOI: 10.1039/C2OB25604E

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