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Issue 20, 2012
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Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

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Abstract

We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.

Graphical abstract: Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

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Publication details

The article was received on 09 Mar 2012, accepted on 10 Apr 2012 and first published on 13 Apr 2012


Article type: Communication
DOI: 10.1039/C2OB25513H
Citation: Org. Biomol. Chem., 2012,10, 4003-4006
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    Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

    Y. Sato, Y. Zhang, T. Seino, T. Sugimoto, S. Nishizawa and N. Teramae, Org. Biomol. Chem., 2012, 10, 4003
    DOI: 10.1039/C2OB25513H

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