A synthesis of the core ring structure of the fargenin/fargenone family of natural products is presented. The general strategy is based upon biosynthetic speculation and exploits a cascade reaction, which transforms a spirocyclic dienone into the core ring system via a deprotonation–oxy-Michael–Wittig olefination sequence. This study represents the first synthesis work towards this family of natural products.
Organic & Biomolecular Chemistry
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