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Issue 15, 2012
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Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines

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Abstract

A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions.

Graphical abstract: Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines

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Publication details

The article was received on 04 Dec 2011, accepted on 23 Feb 2012 and first published on 24 Feb 2012


Article type: Communication
DOI: 10.1039/C2OB07030H
Citation: Org. Biomol. Chem., 2012,10, 2955-2959
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    Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines

    V. O. Iaroshenko, I. Knepper, M. Zahid, R. Kuzora, S. Dudkin, A. Villinger and P. Langer, Org. Biomol. Chem., 2012, 10, 2955
    DOI: 10.1039/C2OB07030H

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