Jump to main content
Jump to site search

Issue 7, 2012
Previous Article Next Article

Olefin cross-metathesis for the synthesis of heteroaromatic compounds

Author affiliations

Abstract

The olefin metathesis reaction has underpinned spectacular achievements in organic synthesis in recent years. Arguably, metathesis has now become the foremost choice for a carboncarbon double bond disconnection. Despite this general utility, de novo routes to heteroaromatic compounds using the cross-metathesis (CM) reaction have only recently emerged as an efficient strategy. This approach allows a convergent union of simple, functionalised, three- to four-carbon olefinic core building blocks, to generate furans, pyrroles and pyridines with a high degree of control of substitution pattern in the product.

Graphical abstract: Olefin cross-metathesis for the synthesis of heteroaromatic compounds

Back to tab navigation

Publication details

The article was received on 30 Sep 2011, accepted on 28 Nov 2011 and first published on 04 Jan 2012


Article type: Emerging Area
DOI: 10.1039/C2OB06659A
Citation: Org. Biomol. Chem., 2012,10, 1322-1328
  •   Request permissions

    Olefin cross-metathesis for the synthesis of heteroaromatic compounds

    T. J. Donohoe, J. F. Bower and L. K. M. Chan, Org. Biomol. Chem., 2012, 10, 1322
    DOI: 10.1039/C2OB06659A

Search articles by author

Spotlight

Advertisements