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Issue 8, 2012
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An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation

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Abstract

A standardized and smooth protocol for solid-phase glycopeptides synthesis under microwave irradiation was developed. Double activation system was proved to allow for highly efficient coupling of Tn-Ser/Thr and bulky core 2-Ser/Thr derivatives. Versatility and robustness of the present strategy was demonstrated by constructing a Mucine-1 (MUC1) fragment and glycosylated fragments of tau protein. The success of this approach relies on the combination of microwave energy, a resin consisting totally of polyethylene glycol, a low excess of sugar amino acid and the “double activation” method.

Graphical abstract: An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation

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Publication details

The article was received on 07 Sep 2011, accepted on 22 Nov 2011 and first published on 22 Nov 2011


Article type: Paper
DOI: 10.1039/C2OB06532K
Citation: Org. Biomol. Chem., 2012,10, 1612-1617
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    An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation

    F. Garcia-Martin, H. Hinou, T. Matsushita, S. Hayakawa and S. Nishimura, Org. Biomol. Chem., 2012, 10, 1612
    DOI: 10.1039/C2OB06532K

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