Issue 5, 2012

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

Abstract

The preparation of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using XtalFluor-E ([Et2NSF2]BF4) as cyclodehydration reagent is described. Various functionalized 1,3,4-oxadiazoles were synthesized and it was found that the use of acetic acid as an additive generally improved the yields.

Graphical abstract: Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

Supplementary files

Article information

Article type
Paper
Submitted
02 Sep 2011
Accepted
27 Oct 2011
First published
07 Dec 2011

Org. Biomol. Chem., 2012,10, 988-993

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

M. Pouliot, L. Angers, J. Hamel and J. Paquin, Org. Biomol. Chem., 2012, 10, 988 DOI: 10.1039/C1OB06512B

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