Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 2, 2012
Previous Article Next Article

Neuronal growth promoting sesquiterpeneneolignans; syntheses and biological studies

Author affiliations


The use of small molecules that can promote neuronal growth represents a promising approach to regenerative science. Along these lines we have developed separate short or modular syntheses of the natural products caryolanemagnolol and clovanemagnolol, small molecules previously shown to promote neuronal growth and induce choline acetyltransferase activity. The postulated biosynthetic pathways, potentially leading to the assembly of these molecules in nature, have guided the laboratory syntheses, allowing the preparation of both natural products in as few as two steps. With synthetic access to the compounds as single enantiomers we have examined clovanemagnolol's ability to promote the growth of embryonic hippocampal and cortical neurons. Clovanemagnolol has been shown to be a potent neurotrophic agent, promoting neuronal growth at concentrations of 10 nM.

Graphical abstract: Neuronal growth promoting sesquiterpene–neolignans; syntheses and biological studies

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 10 Aug 2011, accepted on 26 Sep 2011 and first published on 27 Sep 2011

Article type: Paper
DOI: 10.1039/C1OB06363D
Citation: Org. Biomol. Chem., 2012,10, 383-393
  •   Request permissions

    Neuronal growth promoting sesquiterpeneneolignans; syntheses and biological studies

    X. Cheng, N. Harzdorf, Z. Khaing, D. Kang, A. M. Camelio, T. Shaw, C. E. Schmidt and D. Siegel, Org. Biomol. Chem., 2012, 10, 383
    DOI: 10.1039/C1OB06363D

Search articles by author