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Issue 2, 2012
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Neuronal growth promoting sesquiterpeneneolignans; syntheses and biological studies

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Abstract

The use of small molecules that can promote neuronal growth represents a promising approach to regenerative science. Along these lines we have developed separate short or modular syntheses of the natural products caryolanemagnolol and clovanemagnolol, small molecules previously shown to promote neuronal growth and induce choline acetyltransferase activity. The postulated biosynthetic pathways, potentially leading to the assembly of these molecules in nature, have guided the laboratory syntheses, allowing the preparation of both natural products in as few as two steps. With synthetic access to the compounds as single enantiomers we have examined clovanemagnolol's ability to promote the growth of embryonic hippocampal and cortical neurons. Clovanemagnolol has been shown to be a potent neurotrophic agent, promoting neuronal growth at concentrations of 10 nM.

Graphical abstract: Neuronal growth promoting sesquiterpene–neolignans; syntheses and biological studies

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Publication details

The article was received on 10 Aug 2011, accepted on 26 Sep 2011 and first published on 27 Sep 2011


Article type: Paper
DOI: 10.1039/C1OB06363D
Citation: Org. Biomol. Chem., 2012,10, 383-393
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    Neuronal growth promoting sesquiterpeneneolignans; syntheses and biological studies

    X. Cheng, N. Harzdorf, Z. Khaing, D. Kang, A. M. Camelio, T. Shaw, C. E. Schmidt and D. Siegel, Org. Biomol. Chem., 2012, 10, 383
    DOI: 10.1039/C1OB06363D

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