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Issue 14, 2013
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Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug

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Abstract

Two new small compounds, which undergo fluoride-mediated self rearrangement, produce active DNA alkylating agent nitrogen mustard leading to DNA damage and finally cell death, providing potential antitumor prodrugs.

Graphical abstract: Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug

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Publication details

The article was received on 29 Nov 2012, accepted on 03 Jan 2013 and first published on 04 Jan 2013


Article type: Paper
DOI: 10.1039/C2OB27324A
Citation: Org. Biomol. Chem., 2013,11, 2365-2369
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    Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug

    J. Wu, R. Huang, T. Wang, X. Zhao, W. Zhang, X. Weng, T. Tian and X. Zhou, Org. Biomol. Chem., 2013, 11, 2365
    DOI: 10.1039/C2OB27324A

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