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Issue 10, 2013
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Orthogonal synthesis of a heterodimeric ligand for the development of the GdIII–GaIII ditopic complex as a potential pH-sensitive MRI/PET probe

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Abstract

A heterodimeric polyaminocarboxylate ligand based on a DO3A-sulfonamide linked to AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetracarboxylic acid) was synthesised via an orthogonal pathway in order to differentiate the two chelating cages and allow the formation of a GdIII–GaIII heteroditopic complex. The goal is to create a smart MRI/PET probe with pH dependent relaxivity and with the bimodal imaging approach that enables direct quantification of the stimulus, in this case pH. A 1H NMR relaxometric study of the Gd–Ga heteroditopic complex addressed the pH modulation of the relaxivity and thus its possible use as an MRI pH sensitive probe.

Graphical abstract: Orthogonal synthesis of a heterodimeric ligand for the development of the GdIII–GaIII ditopic complex as a potential pH-sensitive MRI/PET probe

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Publication details

The article was received on 12 Nov 2012, accepted on 02 Jan 2013 and first published on 03 Jan 2013


Article type: Paper
DOI: 10.1039/C2OB27200H
Citation: Org. Biomol. Chem., 2013,11, 1683-1690
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    Orthogonal synthesis of a heterodimeric ligand for the development of the GdIII–GaIII ditopic complex as a potential pH-sensitive MRI/PET probe

    N. Vologdin, G. A. Rolla, M. Botta and L. Tei, Org. Biomol. Chem., 2013, 11, 1683
    DOI: 10.1039/C2OB27200H

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