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Dipartimento di Scienze e Innovazione Tecnologica, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Viale T. Michel 11, I-15121 Alessandria, Italy
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Org. Biomol. Chem., 2013,11, 1683-1690
12 Nov 2012,
02 Jan 2013
First published online
03 Jan 2013
A heterodimeric polyaminocarboxylate ligand based on a DO3A-sulfonamide linked to AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetracarboxylic acid) was synthesised via an orthogonal pathway in order to differentiate the two chelating cages and allow the formation of a GdIII–GaIII heteroditopic complex. The goal is to create a smart MRI/PET probe with pH dependent relaxivity and with the bimodal imaging approach that enables direct quantification of the stimulus, in this case pH. A 1H NMR relaxometric study of the Gd–Ga heteroditopic complex addressed the pH modulation of the relaxivity and thus its possible use as an MRI pH sensitive probe.
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Organic & Biomolecular Chemistry
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