A new efficient enantioselective conjugate addition strategy has been disclosed to rapidly construct 2-amino-3-nitrile-chromene complexes via a multi-hydrogen-bond cooperative activation model.
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Organocatalytic conjugate addition promoted by multi-hydrogen-bond cooperation: access to chiral 2-amino-3-nitrile-chromenes
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Department of Chemistry, National University of Singapore, Block S15, Level 5, 3 Science Drive 3, Singapore 11754, Singapore
E-mail: chmwangj@nus.edu.sg ;
Fax: +(65) 6779 169 ;
Tel: +(65) 6516 1760
E-mail: chmwangj@nus.edu.sg ;
Fax: +(65) 6779 169 ;
Tel: +(65) 6516 1760
Org. Biomol. Chem., 2013,11, 400-406
DOI: 10.1039/C2OB27102H
Received 28 Oct 2012, Accepted 20 Nov 2012
First published online 21 Nov 2012
Organic & Biomolecular Chemistry
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