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Issue 7, 2013
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A general solid phase method for the synthesis of depsipeptides

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Abstract

Herein we describe the synthesis of depsipeptide sequences in which the backbone is composed of alternating esters and amides. Our methodology is based on the synthesis and protection of a depsidipeptide block, which is used as the growing unit for manual SPPS. We have explored Fmoc/OBzl and Fmoc/tBu SPPS strategies, and found the latter to be most compatible with our methodology.

Graphical abstract: A general solid phase method for the synthesis of depsipeptides

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Publication details

The article was received on 26 Sep 2012, accepted on 21 Dec 2012 and first published on 02 Jan 2013


Article type: Paper
DOI: 10.1039/C2OB26893K
Citation: Org. Biomol. Chem., 2013,11, 1167-1170
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    A general solid phase method for the synthesis of depsipeptides

    M. M. Nguyen, N. Ong and L. Suggs, Org. Biomol. Chem., 2013, 11, 1167
    DOI: 10.1039/C2OB26893K

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