An asymmetric biomimetic transamination of aromatic ketones to optically active amines with o-HOPhCH2NH2 as amine source catalyzed by hydroquinine-derived chiral base is described. Up to 85% ee was obtained.
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Organocatalytic asymmetric biomimetic transamination of aromatic ketone to optically active amine
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a
Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b
Department of Chemistry, Colorado State University, Fort Collins, USA
E-mail: yian@lamar.colostate.edu ;
Fax: +001-970-4911801 ;
Tel: +001-970-4917424
E-mail: yian@lamar.colostate.edu ;
Fax: +001-970-4911801 ;
Tel: +001-970-4917424
Org. Biomol. Chem., 2012,10, 8960-8962
DOI: 10.1039/C2OB26782A
Received 11 Sep 2012, Accepted 04 Oct 2012
First published online 05 Oct 2012
Organic & Biomolecular Chemistry
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