Thiol-inducible direct fluorescence monitoring of drug release

Jun Wu; Rong Huang; Changcheng Wang; Wenting Liu; Jiaqi Wang; Xiaocheng Weng; Tian Tian; Xiang Zhou

doi:10.1039/C2OB26680F

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Organic & Biomolecular Chemistry

Issue 4, 2013

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Thiol-inducible direct fluorescence monitoring of drug release

Jun Wu,^a Rong Huang,^a Changcheng Wang,^a Wenting Liu,^a Jiaqi Wang,^a Xiaocheng Weng,^a Tian Tian^a and Xiang Zhou*^a^b

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College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan, P. R. China
E-mail: xzhou@whu.edu.cn ;
Fax: +86-27-87336380 ;
Tel: +86-27-61056559

State Key Laboratory of Natural and Biomimetic Drugs, Beijing University, P. R. China

Org. Biomol. Chem., 2013,11, 580-585

DOI: 10.1039/C2OB26680F
Received 26 Aug 2012, Accepted 02 Nov 2012
First published online 02 Nov 2012

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A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.

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Jun Wu
Rong Huang
Changcheng Wang
Wenting Liu
Jiaqi Wang
Xiaocheng Weng
Tian Tian
Xiang Zhou

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