A one-pot dual functionalization of indoles has been developed. The simultaneous C3-formylation and N-aminomethylation of indoles can be achieved using readily available potassium iodide as a catalyst and tert-butyl peroxybenzoate as a co-oxidant.
The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor
3.696
48 Issues per Year
Indexed in MEDLINE
Communication
Potassium iodide catalyzed simultaneous C3-formylation and N-aminomethylation of indoles with 4-substituted-N,N-dimethylanilines
Show Affiliations
Hide Affiliations
*
Corresponding authors
a
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, 94 Weijin Road, Tianjin 300071, China
E-mail: wangbin@nankai.edu.cn ;
Fax: (+86)-22-23507760 ;
Tel: (+86)-22-23506290
E-mail: wangbin@nankai.edu.cn ;
Fax: (+86)-22-23507760 ;
Tel: (+86)-22-23506290
Org. Biomol. Chem., 2012,10, 9519-9522
DOI: 10.1039/C2OB26636A
Received 17 Aug 2012, Accepted 01 Nov 2012
First published online 01 Nov 2012
Organic & Biomolecular Chemistry
- Information Point
Supplementary Info
-
Supplementary information
PDF (3521K)