Jump to main content
Jump to site search

Issue 42, 2012
Previous Article Next Article

Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes

Author affiliations

Abstract

[2,5-Dimethylfuran]-protected maleimides were placed at both internal positions and the 3′-end of oligonucleotides making use of solid-phase synthesis procedures. A new phosphoramidite derivative and a new solid support incorporating the protected maleimide moiety were prepared for this purpose. In all cases maleimide deprotection (retro-Diels–Alder reaction) followed by reaction with thiol-containing compounds afforded the target conjugate.

Graphical abstract: Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 20 Apr 2012, accepted on 07 Sep 2012 and first published on 10 Sep 2012


Article type: Paper
DOI: 10.1039/C2OB26514A
Citation: Org. Biomol. Chem., 2012,10, 8478-8483
  •   Request permissions

    Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes

    A. Sánchez, E. Pedroso and A. Grandas, Org. Biomol. Chem., 2012, 10, 8478
    DOI: 10.1039/C2OB26514A

Search articles by author