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State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China
; Fax: +86 10 82805496
; Tel: +86 10 82801714
Org. Biomol. Chem., 2012,10, 7869-7871
21 Jul 2012,
24 Aug 2012
First published online
28 Aug 2012
We have developed a new KI-catalyzed method for the imidation of an sp3 C–H bond adjacent to an amide nitrogen atom by using TBHP (tert-butyl hydroperoxide, 70% aqueous solution) as the oxidant. This novel procedure tolerated air and moisture and provided a series of novel products in moderate to excellent yields under mild conditions.