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State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University, Tianjin 300071, People's Republic of China
; Fax: (+86) 22-23503627
; Tel: (+86) 22-23503159
Org. Biomol. Chem., 2012,10, 7628-7634
25 Mar 2012,
01 Aug 2012
First published online
02 Aug 2012
A novel phosphine-catalyzed intermolecular [3 + 2] cycloaddition of ynones and N-substituted isatins was developed. In this reaction, substituted ynones, serving as a C3 synthon, were successfully applied in intermolecular annulation reactions. A number of functionalized spirooxazolines were obtained in high yields and stereoselectivity.