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Issue 37, 2012
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Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines

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Abstract

A novel phosphine-catalyzed intermolecular [3 + 2] cycloaddition of ynones and N-substituted isatins was developed. In this reaction, substituted ynones, serving as a C3 synthon, were successfully applied in intermolecular annulation reactions. A number of functionalized spirooxazolines were obtained in high yields and stereoselectivity.

Graphical abstract: Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines

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Publication details

The article was received on 25 Mar 2012, accepted on 01 Aug 2012 and first published on 02 Aug 2012


Article type: Paper
DOI: 10.1039/C2OB26338F
Citation: Org. Biomol. Chem., 2012,10, 7628-7634
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    Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines

    L. Yang, P. Xie, E. Li, X. Li, Y. Huang and R. Chen, Org. Biomol. Chem., 2012, 10, 7628
    DOI: 10.1039/C2OB26338F

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