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Synthesis and properties of novel L-isonucleoside modified oligonucleotides and siRNAs

Jun Zhang,a   Yue Chen,a   Ye Huang,a   Hong-Wei Jin,a   Ren-Ping Qiao,a   Lei Xing,a   Liang-Ren Zhang,a   Zhen-Jun Yang*a and   Li-He Zhang*a  
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State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
E-mail: zdszlh@bjmu.edu.cn, yangzj@bjmu.edu.cn ;
Tel: +86-10-82802503
Org. Biomol. Chem., 2012,10, 7566-7577

DOI: 10.1039/C2OB26219C
Received 28 Apr 2012, Accepted 31 Jul 2012
First published online 02 Aug 2012

This article is part of themed collection: Nucleic acids: new life, new materials
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