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Issue 42, 2012
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Gas extrusion in natural products total synthesis

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Abstract

The thermodynamic driving force from the release of a gaseous molecule drives a broad range of synthetic transformations. This review focuses on gas expulsion in key reactions within natural products total syntheses, selected from the past two decades. The highlighted examples survey transformations that generate sulfur dioxide, carbon dioxide, carbonyl sulfide, or nitrogen through polar, radical, pericyclic, photochemical, or organometallic mechanisms. Of particular interest are applications wherein the gas extrusion enables formation of a synthetically challenging motif, such as an unusually hindered or strained bond.

Graphical abstract: Gas extrusion in natural products total synthesis

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Publication details

The article was received on 16 Jun 2012 and first published on 09 Aug 2012


Article type: Perspective
DOI: 10.1039/C2OB26152A
Citation: Org. Biomol. Chem., 2012,10, 8383-8392
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    Gas extrusion in natural products total synthesis

    X. Jiang, L. Shi, H. Liu, A. H. Khan and J. S. Chen, Org. Biomol. Chem., 2012, 10, 8383
    DOI: 10.1039/C2OB26152A

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