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Issue 41, 2012
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Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease

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Abstract

Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP).

Graphical abstract: Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease

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Publication details

The article was received on 07 Jun 2012, accepted on 02 Aug 2012 and first published on 03 Aug 2012


Article type: Paper
DOI: 10.1039/C2OB26103K
Citation: Org. Biomol. Chem., 2012,10, 8216-8235
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    Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease

    P. Linning, U. Haussmann, I. Beyer, S. Weidlich, H. Schieb, J. Wiltfang, H. Klafki and H. Knölker, Org. Biomol. Chem., 2012, 10, 8216
    DOI: 10.1039/C2OB26103K

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