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Issue 35, 2012
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A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp

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Abstract

Azaphilone derivatives 1 and 2 and a novel tricyclic polyketide 3, together with a known azaphilone, austdiol (4), were isolated from the endophytic fungus Dothideomycete sp., which was isolated from a Thai medicinal plant, Tiliacora triandra. Compound 3 is the first polyketide having a tricyclic 6,6,6 ring system, which is similar to that of a terpenoid skeleton. The absolute configurations of stereogenic centers in 1–3 were addressed by Mosher's method and biosynthetic analogy with a known azaphilone isolated from the same fungus. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated.

Graphical abstract: A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp

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Publication details

The article was received on 18 May 2012, accepted on 05 Jul 2012 and first published on 05 Jul 2012


Article type: Paper
DOI: 10.1039/C2OB25959A
Citation: Org. Biomol. Chem., 2012,10, 7220-7226
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    A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp

    S. P. D. Senadeera, S. Wiyakrutta, C. Mahidol, S. Ruchirawat and P. Kittakoop, Org. Biomol. Chem., 2012, 10, 7220
    DOI: 10.1039/C2OB25959A

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