Jump to main content
Jump to site search

Issue 37, 2012
Previous Article Next Article

Camphor-derived C1-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones

Author affiliations

Abstract

A series of stable C1-symmetric chiral diamines (2a–2l) were conveniently synthesized by condensing exo-(−)-bornylamine or (+)-(1S,2S,5R)-menthylamine with various commercially available Cbz-protected amino acids. Among them, 2a can efficiently promote the Michael addition of nitroalkanes to a broad scope of enones with high yields (up to 96%) and excellent enantioselectivities (up to 98%) under mild conditions.

Graphical abstract: Camphor-derived C1-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 May 2012, accepted on 20 Jul 2012 and first published on 24 Jul 2012


Article type: Paper
DOI: 10.1039/C2OB25922B
Citation: Org. Biomol. Chem., 2012,10, 7618-7627
  •   Request permissions

    Camphor-derived C1-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones

    Y. Zhou, Q. Liu and Y. Gong, Org. Biomol. Chem., 2012, 10, 7618
    DOI: 10.1039/C2OB25922B

Search articles by author

Spotlight

Advertisements