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Issue 38, 2012
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One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature

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Abstract

An efficient general synthetic approach has been developed to synthesize pyrazole-containing bisphosphonate (N-BPs) esters from chromenone derivatives via a sequential two-step reaction in one pot at ambient temperature in good to excellent yields. This protocol provides a new convenient method to prepare lipophilic bisphosphonate precursors with potential activities.

Graphical abstract: One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature

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Publication details

The article was received on 09 May 2012, accepted on 29 Jul 2012 and first published on 02 Aug 2012


Article type: Paper
DOI: 10.1039/C2OB25889G
Citation: Org. Biomol. Chem., 2012,10, 7730-7738
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    One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature

    H. Xiang, X. Qi, Y. Xie, G. Xu and C. Yang, Org. Biomol. Chem., 2012, 10, 7730
    DOI: 10.1039/C2OB25889G

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