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Issue 36, 2012
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From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

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Abstract

Indolo[3,2-c]quinolines are pharmacologically attractive class of heterocyclic compounds. The method of their synthesis, based on transformation of furfural, which is a large-scale product of treatment of biomass including agricultural and forestry wastes, has been developed. This method was utilized for the total synthesis of antimalarial alkaloid isocryptolepine and its derivatives.

Graphical abstract: From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

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Publication details

The article was received on 01 May 2012, accepted on 06 Jul 2012 and first published on 09 Jul 2012


Article type: Communication
DOI: 10.1039/C2OB25836F
Citation: Org. Biomol. Chem., 2012,10, 7262-7265
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    From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

    M. G. Uchuskin, A. S. Pilipenko, O. V. Serdyuk, I. V. Trushkov and A. V. Butin, Org. Biomol. Chem., 2012, 10, 7262
    DOI: 10.1039/C2OB25836F

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