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Issue 30, 2012
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Methylthioxylose – a jewel in the mycobacterial crown?

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Abstract

Ten years ago an unusual sugar was discovered in a cell wall polysaccharide of Mycobacterium tuberculosis. Structural elucidation revealed the presence of the first thiosugar in a bacterial polysaccharide. Synthetic studies have helped to define its relative and absolute configuration as α-D-methylthioxylofuranosyl. While its biosynthetic origins remain the subject of speculation, work has begun to define its possible biological roles.

Graphical abstract: Methylthioxylose – a jewel in the mycobacterial crown?

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Publication details

The article was received on 27 Mar 2012, accepted on 12 Apr 2012 and first published on 10 May 2012


Article type: Perspective
DOI: 10.1039/C2OB25630D
Citation: Org. Biomol. Chem., 2012,10, 5698-5706
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    Methylthioxylose – a jewel in the mycobacterial crown?

    W. B. Turnbull and S. A. Stalford, Org. Biomol. Chem., 2012, 10, 5698
    DOI: 10.1039/C2OB25630D

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