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Issue 30, 2012
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Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism

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Abstract

A catalytic Mannich reaction of a simple ester with no activating functionality at the α-position via a product-base mechanism was reported. The desired Mannich adducts were obtained in high yields using a catalytic amount of KH. This is a rare example of a Brønsted base-catalyzed Mannich reaction of unactivated esters as substrates.

Graphical abstract: Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism

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Publication details

The article was received on 10 Mar 2012, accepted on 02 Apr 2012 and first published on 03 Apr 2012


Article type: Communication
DOI: 10.1039/C2OB25522G
Citation: Org. Biomol. Chem., 2012,10, 5750-5752
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    Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism

    Y. Yamashita, H. Suzuki and S. Kobayashi, Org. Biomol. Chem., 2012, 10, 5750
    DOI: 10.1039/C2OB25522G

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